Mittwoch, 28. November 2012

Silver Linings Playbook and Moonrise Kingdom lead Spirit field


Silver Linings Playbook and Moonrise Kingdom lead Spirit field

Kara Hayward and Jared Gilman in Moonrise Kingdom and Bradley Cooper in Silver Linings PlaybookBoth Moonrise Kingdom (left) and Silver Linings Playbook are nominated for best picture, director and screenplay

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Quirky comedies Silver Linings Playbook and Moonrise Kingdom will lead the field at next year's Spirit Awards, having received five nominations each.
Both films are competing for the best picture and best director prizes at the awards, which honour independent films.
Also up for best picture are father-daughter tale Beasts of the Southern Wild, black comedy Bernie and Keep the Lights On, a drama about a gay romance.
The winners will be announced on 23 February, one day before the Oscars.
Bradley Cooper and Jennifer Lawrence have both been nominated for their lead roles in Silver Linings Playbook.
The pair play a manic depressive and a young widow who strike up an unusual romance in David O Russell's hotly tipped awards contender.
The film is also nominated for best screenplay, along with Moonrise Kingdom.
Wes Anderson's first-love story between a precocious boy and girl also received a best supporting actor nod for Bruce Willis and another nomination for its cinematography.
'Strong group'
Matthew McConaughey receives two nominations: for best actor in crime thriller Killer Joe, and best supporting actor in male stripper comedy Magic Mike.
John Hawkes and Helen Hunt are recognised for their performances as a disabled man and his sex surrogate in The Sessions.
Other acting nominees include Jack Black for Bernie, Michael Pena for End of Watch, Sam Rockwell for Seven Psychopaths and Mary Elizabeth Winstead for Smashed.
There is also a best actress nomination for child star Quvenzhane Wallis for her role in Beasts of the Southern Wild, which won the top prize at the Sundance Film Festival in January.
"The nominations this year represent an astonishingly strong group of artists both in front of and behind the camera," said Josh Welsh, co-president of awards organisers Film Independent.
Spirit nominations often overlap with Oscar contenders. The Artist won four awards last year, then went on to win five Oscars the following day.
http://www.bbc.co.uk/news/entertainment-arts-20523244

Concern at outsourced clinical trials in developing world


Concern at outsourced clinical trials in developing world

Few drug companies have robust measures to ensure outsourced clinical trials in developing countries are safe and ethical, an independent report says.
Most provided no evidence of exerting real influence over the way the trials were conducted by contractors, the latest Access to Medicine Index said.
However, the report also praised firms for stepping up their efforts to provide affordable medicines.
Published every two years, it ranks the world's 20 biggest drug companies.
GlaxoSmithKline remains at the top of the index, followed closely by Johnson & Johnson and Sanofi. AstraZeneca slipped down the rankings most significantly.
This is the third report by the Netherlands-based index, which is funded by organisations including the Bill and Melinda Gates Foundation and the UK's Department for International Development.
It is estimated that one billion people around the world are unable to afford the medicines they need.

“Start Quote

Anything putting patients at risk is an unacceptable practice and a significant concern.”
David SampsonAccess to Medicine Index
The index report says that the drive to improve access "has landed in more boardrooms", with companies discounting products by as much as 50-60% - although sometimes it was difficult to ascertain the true baseline price.
But it urges all the firms to be more transparent about their lobbying practices.
Patients at risk
One of the authors, David Sampson, said: "Even though we raised the bar on our measures this year, and the economic climate has been difficult in the last few years, all of the companies have improved their approach and initiatives on access.
"Boards are taking control of this issue - and what they care about gets managed, measured and motivated in a way that flows through the organisation.
"There's an increasing trend to outsource clinical trials - but as is always the case with outsourcing, the relationship between the two parties needs to be extremely tightly defined and managed carefully.
"While most companies talk about codes of conduct and audit, only four companies disclosed details of disciplinary action that had taken place when conduct had fallen short.
"Regulatory regimes in developing countries are more variable - and anything putting patients at risk is an unacceptable practice and a significant concern."
The index also examined what pharmaceutical products were being developed. Drugs to tackle the big killer diseases such as respiratory and diarrhoeal infections, Aids and malaria continued to be the primary focus - but more attention was being paid to some of the neglected tropical diseases.
More companies were found to be running "tiered pricing" schemes, in which medicines are cheaper for targeted countries or populations. The report authors said these should be expanded.
One example was the varying prices charged by Bayer in 11 sub-Saharan African countries, to help increase access to its contraceptive pill.
GlaxoSmithKline was praised for making its entire vaccine portfolio available to developing countries at an equitable price, though the index said it should reveal more about its marketing and promotional programmes.
AstraZeneca dropped from seventh to 16th place in the index "largely due to the fact that it has not made many advances in its access to medicine approach" since the previous report.
The company said the latest report was only one of several measures that provide an insight into medicine access and did not take full account of AstraZeneca's significant activities that promote better access to healthcare.
"Our core therapeutic focus is in chronic illnesses, which are responsible for an increasingly larger share of the disease burden in developing countries but are only partially considered by the Index," said a spokeswoman.
GSK chief executive Sir Andrew Witty said: "Enabling greater access to medicines is firmly at the heart of our business."
He said GSK's ranking was recognition of this, but added: "We recognise there is more we can do, and we will continue to challenge ourselves to adopt and deliver new ideas and approaches to improve lives around the world."
http://www.bbc.co.uk/news/health-20468396

Dienstag, 28. August 2012

For the Overweight, Bad Advice by the Spoonful


Two-thirds of Americans are overweight or obese. For most, research shows, neither diets nor moderate exercise brings significant long-term weight loss.

College Fitness: 5 Tips for Staying in Shape


Many college freshmen are flocking to campuses this month, in cars packed with dorm accessories—and perhaps tearful parents. After students say goodbye to their families and hello to their new roommates, the enormous lifestyle changes of college life will start setting in: Tougher classes. All-nighters. Shared rooms. Parties. Because of these newfound freedoms, distractions, and a slowing metabolism, it's common for students to become unhealthy and perhaps gain weight. Some may know it as the dreaded Freshman 15, others as the Freshman 25.
"In high school, [students] may have played sports or taken P.E. classes, so they had activity built into their lives," says Dixie Stanforth, fitness expert and lecturer in the University of Texas—Austin's kinesiology and health education department. Now, she says, students have many more decisions that they're allowed to make on their own. "Nobody's telling them to study; Nobody's telling them to exercise and eat right," notes Stanforth. "[Before college], they didn't get to choose Wendy's for lunch."
By exercising regularly and eating healthfully, both freshmen and older college students can stay fit. Here are some tips:
Make a plan.
Stanforth suggests students map out a specific fitness schedule at the beginning of the semester. "If all I do is think, 'Oh, I really should exercise,' [then] I'm not going to exercise," she says. "It's just not going to happen." 
Students should examine their fall semester course load and determine exactly how and when they will make time for exercise. Will they bring their swim suit to that noon history class and head to the aquatic center afterward? Will they bike to and from the dining halls? Will they hit the elliptical after filing stories for the student newspaper? The trick is to be realistic, says Silvia Baage, a group fitness instructor and Ph.D. student at the University of Maryland. "If you have an 8 a.m. class every day, you're probably not going to work out at 6 a.m." 
Join a club (or make your own). 
When students find friends who also want to exercise regularly, those friends will likely hold them to it, says Stanforth."Doing some type of team activity or intramural sport—or something in which other people are counting on you—that's very powerful," she adds.
Often, dorm lobbies and recreation center bulletin boards include flyers for like-minded exercisers who want to create cycling clubs, swim teams, rock-climbing crews, or just about anything else, says John Katsares, personal training coordinator at the Ohio State University. Students should look for these flyers, and if they don't see anything of interest, make their own club.
Joining a fitness club can also help students make friends, says Megan Alexander, a graduate assistant who works with Katsares in Ohio State's department of recreational sports. "Coming into college as a freshman, you're sort of looking for that place to belong," she says. "So having that group can help you feel a lot more supported." 
[See U.S. News's Eat + Run blog, which serves up fresh diet and fitness advice daily.]
Sign up for an intramural sport. 
Andrew Dubs, an assistant track and field coach at the University of North Carolina, trains and conditions varsity athletes. But for students who want to go a different route, Dubs suggests signing up for an intramural sport.
Intramurals are a great way to bond with classmates and try different sports, such flag football, dodgeball, and disc golf. Plus, he says, with a league-organized game schedule, students can more easily plan their workouts. "With intramurals, that's an hour [of exercise] at night maybe once or twice a week," he says. "Then two or three other times a week, you can do something on your own. 
Embrace the dorm workout.
Ideally, says Baage, students should get out of their living quarters to exercise—be it in the gym, on a bike path, in a pool, or wherever. But with bad weather and crammed study schedules, that's not always an option.
For working out in a small space, such as a dorm room, Baage suggests using a resistance band. (They're sold at Target, Walmart, and most major retailers.) With a resistance band, which is ultimately an oversized rubber band that sometimes has handles, "you can do squats, lunges, bicep extensions, bicep curls—you can do everything," she says.
A stability ball—a large, inflatable, rubber ball—can also help students work their abs and other muscles, as sitting on the round surface requires balance. "You could be sitting in front of your computer, and by sitting on the ball instead of the chair," she says, "you're working on your core at the same time."
Walk the campus. 
"Students should try to walk as much of their campus as they can," says Stanforth. Whenever possible, she suggests forgoing the ride to class or cross-campus bus service, and walking to classes instead.
Another simple, everyday fitness tip from Stanford: Take the stairs in classroom buildings instead of the elevator. "Build those routine levels of activity," she says, "All those calories add up."
Tags:
 
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University of Maryland, 
University of Texas, 
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University of North Carolina


How Lying Affects Your Health


To tell the truth, honesty may be the best policy, for physical and mental reasons

The best time to invest in gold shares


Those who read the magazine or watch this website know that we like both gold and gold mining shares.
However, in recent years gold miners haven’t done that well. Indeed, in the last year, the FTSE Gold Mines Index has gone down by 25%.
We think this presents an opportunity for investors who get their timing right. To understand the best time to invest, I recently spoke to Georges Lequime of Earth Resources Investment Group (ERIG). He helps run the award winning Earth Gold Fund.

The cost of exploration and mining are rising

The core reason why we’re bullish on gold is as a hedge against inflation. Whether it works to do anything for growth or not, we can expect the US and Europe in particular to print a lot more money over the next few years. At the same time, interest rates will remain rock bottom in nominal terms, and negative in real terms. We also think Asian demand, especially from an imploding China, will play a major role.
However, the costs of finding gold and getting it out of the ground are starting to rise. Ten years ago the major producers spent $194 in cash and $66 in capital expenditures for each ounce of gold produced. In the first quarter of this year, this had risen to a $627 in cash and $603 in capital. In total, each ounce of gold now costs $1,384 in Q1 2012, compared with $253 in 2002.
ERIG also note that along with increased costs, the remaining reserves of gold are harder to mine. In the 1950s, a ton of ore would yield 6g of solid gold on average. By 1980, the same amount would have only produced 2.32g. The average is now 1.1g – and is still falling. Lower grades mean that more machines and tools are needed. In turn this has led to the rise of highly capital-intensive mega-mines, which attempt to take advantage of economies of scale.
Any company that has, or is able to find, cost-effective gold reserves should still do very well. But the pressure is mounting on the smallest players. 

The three stages of gold companies

When investing in gold shares, or any mining or resource companies, it is important to find the right point to jump in. Most companies go through four stages.
In the first stage, companies try to find gold deposits. During this period they tend to have a very low value. These companies either run out of cash and fold, or manage to uncover evidence that there might be some gold reserves.
In the second stage, they try to examine these reserves and see whether they can be turned into a viable mine. These shares typically surge as investors pile in, attracted by the story. However, they quickly become bored with the lack of news. By the time the feasibility study is completed, they are usually back down to the level they were at the end of stage one.
If the report indicates that it is worth building a mine, then the final stage begins. During this period the firm tries to raise more capital and starts building the mine. As construction starts, gold starts coming out of the ground, and the company starts making money, brokers and institutions start becoming interested. The share price starts rising again.
Finally, the mine starts nearing the end of its natural life as reserves become exhausted. While the firm may be making large profits, and paying high dividends, it will need to find new opportunities in order to survive. This can be either through expansion, exploration or buying other mines.
While it is possible to make money during any part of the cycle, the best time to invest is at the end of stage two, or at the start of stage three. This is because the shares are cheap, thanks to bored investors, but the company is much closer to starting production.
In contrast, the most risky time to invest is at the start and middle of stage two during the 'hype' phase. While profits can be made in this period, you will need to be very good at reading sentiment, and predicting when it will change.

A gold miner to tuck away

One company that fits the profile is Eldorado Gold (NYSE: EGO). While it is technically a mature company, it has used the cash received from operations to takeover other firms that are in the process of building mines. In effect, it has transformed itself into a late second stage/early third stage company.
Of course, this doesn’t come cheap. M&A costs and the capital investment involved in developing its new reserves have hit profits (the firm now trades at a price/earnings ratio (p/e) of 25). It also means that a large part of its business is now in Greece. Due to fears about the consequences of a possible Greek exit, shares in Eldorado have been hit badly.
However, it should secure the firm’s long-term future. A Greek exit should be positive for exporters since it will bring down real wages more quickly than if Greece stayed in the euro. Unless Athens quits the EU altogether, it will still benefit from access to the European market.


“Look at me – I’m a thieving enemy of the people”


If you lived in Italy today would you buy a new super yacht? I suspect you would not. Why? Because the taxman might see it and if he did he might pop round to ask exactly how you paid for it.
And given the size of the black economy in Italy, that might be a question you didn’t want to answer.
But it might not be just yachts you are shying away from splashing out on. And your reluctance to spend may have nothing to do with being Italian or owning Italian assets.
Across the globe there are signs that high-end buyers of luxury goods are closing their wallets. Tax is one reason. Another is that ostentatious wealth is no longer admired or accepted in the way that it was. And that’s bad news for luxury goods shares.

The Italian government takes no prisoners

If you are in any doubt about the scale of the super yacht exodus have a quick look at this report on empty marinas across Italy.
Meanwhile who’d want a new Ferrari after last year’s campaign against tax evaders – which involved tax inspectors raiding the owners of luxury cars in smart ski resorts and visiting Ferrari-owner events to check the tax returns of every single driver?
And who’d want a luxury car at all given that not only will the taxman be checking your old tax returns if he sees you in a Lamborghini, he’ll also be asking for more: new taxes mean that, owners of the €316,000 Lamborghini Aventador now pay about €8,400 a year in tax.
The answer it seems is no one: according to the blogging hedge fund manager at www.macro-man.blogspot.com the “persecution of Ferrari owners” has become so severe that they are selling them in their thousands. You can now pick one up for the “price of a new VW Polo”.
This is nasty news for Ferrari and its competitors. Not only are sales being hit by general austerity and shocking enforcement of the law, but global second hand prices are likely to be hit by the new exodus of cars from Italy (note that the number of high performance second hand cars exported from Italy tripled to 13,633 in the first five months of 2012 on numbers from auto industry group Unrae).
This is going to be “a vicious value collapse” says Macro Man.

This isn’t just an Italian theme

But it isn’t just in Italy that the luxury goods market is beginning to look a little shaky.
The market’s worriers have this week turned their attention to Chinese jewelry firm Hengdeli – the leading retailer of Swiss watches in China.
I’ve written here before about John Hempton at Bronte Capital and his idea that sales tax receipts from Hong Kong suggest falling sales of the likes of jewelry and watches in Hong Kong. Recent results from Hengdeli back up his argument.